ABSTRACT
Background: Acute kidney injury [AKI] often occurs as a result of ischemia-reperfusion. AKI is a major renal disease associated with high mortality rate. We investigated the renal protective effects of gallic acid and L-carnitine on the blood factors in rat model of renal ischemia-reperfusion
Materials and methods: In this experimental study, forty male Wistar rats were randomly divided into 4 groups: controls, ischemia/reperfusion group [I/R], ischemia-reperfusion+L-carnitine [I/R+Lc, 500mg/kg], and ischemia/reperfusion + gallic acid [I/R+GA, 100mg/kg]. Animals of the experimental groups were subjected to unilateral nephrectomy and received Gallic acid and L-carnitine for 14 days. Then, ischemia was induced by clamping the renal pedicle for 45 minutes. 72 h later, they were sacrificed, and the blood level of BUN, uric acid and creatinine were analyzed
Results: The results showed a significant increase in BUN and creatinine of I/R group compared to the controls. Also, BUN and creatinine were significantly decreased in I/R+Lc and I/R+GA groups in comparison with I/R group. On other hand, blood level of uric acid was decreased in I/R+GA group compared to I/R group
Conclusion: The results indicated that ischemia/reperfusion induced acute renal injury in rat model, and pretreatment with L-carnitine and gallic acid can prevent the kidney tissue damage from renal ischemia